DISCOVER THE RENAL PROBLEM WITH GOUT
It has long been known that high serum uric acid (sUA) levels and urate deposition can have disastrous consequences for bones and joints.1-3 But what effect does uric acid have on the kidney? Current research shows an association between elevated sUA levels and the progression of chronic kidney disease (CKD).4-6
ANY GOUTY KIDNEY CAN BE A URIC ACID VICTIM
Watch the Down and Out Kidney video and see what can happen to the kidney when uric acid goes unchecked.
THERE IS A 10-FOLD INCREASE IN GOUT PREVALENCE WHEN eGFR <60 mL/min7*
Patients with stage 3 or 4 CKD have a 10-fold increase in gout prevalence compared with patients with normal renal function.7
- CKD=chronic kidney disease; eGFR=estimated glomerular filtration rate.
- *Post hoc, cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data from 2009 to 2010 of adults >20 years of age. Error bars are 95% CI.7
- Severe <30
- Moderate 30-59
- Mild 60-89
- Normal ≥90
Review the latest research on the relationship between uric acid levels, gout, and CKD
High sUA levels connected to CKD progression
An analysis of a cohort study found that higher baseline uric acid levels were associated with the progression of CKD. Researchers found that the risk of renal failure increased by 28% for every 1 mg/dL increase in baseline uric acid levels.4READ FULL ARTICLE
Gout linked to progression of kidney disease to advanced CKD
In a retrospective study of more than 623,000 patients, gout was found to be significantly associated with a 29% higher risk of CKD progression to advanced kidney disease, including diagnosis of end-stage renal disease.5READ FULL ARTICLE
Gout associated with higher risk of developing CKD
In one of the largest studies of its kind in nephrology, close to 1.7 million U.S. medical records were analyzed and showed that gout is associated with a 3-fold higher risk of developing CKD in older adults.6READ FULL ARTICLE
- Doghramji PP, et al. Postgrad Med. 2012;124:98-109.
- McQueen FM, et al. Nat Rev Rheumatol. 2012;8:173-181.
- Dalbeth N, et al. Ann Rheum Dis. 2015;74:1030-1036.
- Oh TR, et al. Sci Rep. 2019;9(6681):1-9.
- Stack AG, et al. BMJ Open. 2019;9:1-7.
- Singh JA, et al. BMC Nephrol. 2019;20(9):1-7.
- Krishnan E. PLoS One. 2012;7(11):e50046.